Registration Dossier
Registration Dossier
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EC number: 905-459-9 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption: expected to be absorbed by oral and inhalation route (less by dermal route)
Distribution: DIPB or its metabolites are expected to be distributed into organs and tissues.
Metabolism: DIPB is expected to be predominantly metabolized via oxidation reactions on the alkyl side chain followed by conjugation reactions.
Excretion: DIPB and its more water-soluble metabolites (alcohols and conjugates) are expected to be efficiently eliminated, mainly in urine.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There is no specific study on DIPB, but there are data on other alkylated benzenes, ascumene (isopropylbenzene) or diethyl benzene, which are close related compounds and which metabolised by alkyl chain hydroxylation; leading to corresponding alcohol metabolites.
Absorption:
Based on its physico-chemical properties (LogKow, water solubility) and the available toxicity data, absorption of DIPB is considered as possible by oral and inhalation, but quantitative information is not available. It is confirmed by data on other alkylated benzenes (like cumene).
Absorption by dermal route is expected to be limited in view of the very low water solubility (that limit the partition from the stratum corneum into the epidermis).
Distribution:
Once absorbed, DIPB or its metabolites are expected to be distributed into organs and tissues.
Metabolism:
As for other alkylated benzene compounds, DIPB is expected to be predominantly metabolized via oxidation reactions on the alkyl side chain followed by conjugation reactions.
Results of metabolism studies conducted on various alkylated benzene compounds indicate that these types of compounds undergo similar routes of metabolic reactions. These reactions are characterized by phase I biotransformations on the alkyl side-chain to form alcohols and/or carboxylic acids. These metabolites are eventually eliminated in the urine following phase II transformations as conjugates of glucuronic acid or glycine
Excretion
DIPB and its more water-soluble metabolites (alcohols and conjugates) are expected to be efficiently eliminated, probably mainly in urine as it is the case for other alkylated benzene.
References:
- USEPA HOV dossier on Diisopropylbenzene category
- WHO CICAD no. 18 (cumene)
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