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EC number: 905-459-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral rat LD50 = 3900 mg/kg bw
inhalation rat 6-hr LC0 > 2100 mg/m3
dermal LD50 rabbits > 3160 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study from 1976 (no guidelines available at the time the study was performed).
Mixed groups of 5 male and female Sprague-Dawley strain albino rats were dosed with undiluted TS via gavage at 4 dose levels. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically. - GLP compliance:
- no
- Remarks:
- Study from 1976 (GLP was not compulsory at the time the study was performed).
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Initial body weights: 220 - 235 g (m) and 225 - 240 g (f)
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 3160, 3980, 5010 or 6310 mg/kg bw
- No. of animals per sex per dose:
- mixed groups of 5 male and female rats
- Control animals:
- no
- Details on study design:
- Survivors were sacrificed 14 days after dosing.
- Statistics:
- No data
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 900 mg/kg bw
- 95% CL:
- >= 3 550 - <= 4 290
- Mortality:
- 3160 mg/kg bw: 0/5
3980 mg/kg bw: 3/5
5010 mg/kg bw: 3/5
6310 mg/kg bw: 5/5
Survival time: 1 - 5 days, most deaths within 2 days. - Clinical signs:
- other: reduced appetite and activity (1 - 3 days in survivors), increasing weakness, collapse and death.
- Gross pathology:
- Decedents: Haemorrhagic areas of the lungs, liver discoloration and acute GI tract inflammation.
Survivors: viscera appeared normal. - Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The oral LD50 value for male and female rats was 3900 mg/kg bw.
- Executive summary:
In this older study mixed groups of 5 male and female Sprague-Dawley strain albino rats were dosed via gavage with undiluted TS at doses of 3160, 3980, 5010 or 6310 mg/kg bw. The oral LD50 value for male and female rats was given with 3900 mg/kg bw. Toxic signs included reduced appetite and activity, increasing weakness, collapse and death. In decedents, haemorrhagic areas of the lungs, liver discoloration and acute GI tract inflammation were noted, while in survivors viscera appeared normal.
As the other data indicated a LD50 higher than this one, it will be taken as the oral LD50 for mix DIPB
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 900 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Guideline:
- other: Study from 1976 (no guidelines available at the time the study was performed).
- Principles of method if other than guideline:
- 6 male SD rats were exposed (whole body) to 2100 mg TS/m3
- GLP compliance:
- no
- Remarks:
- Study from 1976 (GLP was not compulsory at the time the study was performed).
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No further data
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Initial sample: 107.2 g
Recovered sample: 104.1 g
Condensed sample: 0.0 g
Vaporised sample: 3.1 g
Chamber temperature: 25 degrees C
Chamber humidity: 80 %
Chamber volume: 35 L
Air flow rate: 4.0 L/min - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- 2100 mg/m3
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Statistics:
- No data
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 2 100 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- 0/6
- Clinical signs:
- other: none
- Body weight:
- No data
- Gross pathology:
- 14 days: viscera appeared normal
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC0 value for male rats was > 2100 mg/m3 for 6h exposure, which corresponds to CL50 / 4h > 3,15 mg/kg. As for cumene (isopropylbenzene) the LC0 is > 5.5 mg/L mist it is anticipated that DIPB LC50 is >5 mg/kg mist.
- Executive summary:
In this older study 6 male Sprague-Dawley strain albino rats were exposed to 2100 mg TS/m3 (whole body) over 6 hrs. None of the animals died and the viscera appeared normal 14 days after dosing. This correspond to CL0 / 4h > 3,15 mg/kg and certainly to a CL50 > 5 mg/L mist with dermal exposure.
There are 2 studies with DIPB and Cumene, indicating LC0 respectively at 2100 mg/m3 (6h) and 17600 mg/m3 (1h), while they have vapour pressure of 0.34 and 4.9 hPa. We do not know really if they are based on saturating Vps, anyway needing to heat the substance which will condensate to aerosol when reaching the rat whole exposure cages. We can estimate the 4 hours value with the Haber law, either with C.t=K or C3.T=K In the first case CL0 would be 3.15 and 5.18 mg/L respectively. In the second case the CL0 will be for DIPB and Cumene of 2.41 and 11.1 mg/L. From these data it is assumed that the CL50 of DIPB is > 5 mg/L aerosol, leading to no CLP classification.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5.5 mg/m³ air
- Quality of whole database:
- Old but sufficent with the supporting data. LC0 >3.15 and isopropylbenzene LC0 >5.5 mg/L. No effects een on animals
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Guideline:
- other: Study from 1976 (no guidelines available at the time the study was performed).
- Principles of method if other than guideline:
- One or two New Zealand Albino rabbits (m or f) in each dosing group were dosed with undiluted TS over 24 hrs. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically.
- GLP compliance:
- no
- Remarks:
- Study from 1976 (GLP was not compulsory at the time the study was performed).
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Initial body weights: 2100 - 2200 g (m) and 1800 - 2200 g (f)
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No further data
- Duration of exposure:
- 24 hrs
- Doses:
- 1000, 2000, 3160, 5010 or 7940 mg/kg bw
- No. of animals per sex per dose:
- 1000 mg/kg bw: 1 m
2000 mg/kg bw: 1 f
3160 mg/kg bw: 1 m
5010 mg/kg bw: 1 f
7940 mg/kg bw: 1 m / 1 f - Control animals:
- not specified
- Details on study design:
- Survivors were sacrificed 14 days after dosing.
- Statistics:
- No data
- Preliminary study:
- Slighty irritating according to Draize socre: not irritating.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Mortality:
- 1000 mg/kg bw: 0/1 m
2000 mg/kg bw: 0/1 f
3160 mg/kg bw: 0/1 m
5010 mg/kg bw: 1/1 f (time to mortality: 4 days)
7940 mg/kg bw: 0/1 m and 1/1 f (time to mortality: 2 days)
Survival time: 2 - 4 days - Clinical signs:
- other: reduced appetite and activity (4 - 7 days in survivors), increasing weakness, collapse and death.
- Gross pathology:
- Decedents: Haemorrhagic areas of the lungs, liver hyperaemia, enlarged gall bladder and GI tract inflammation.
Survivors: viscera appeared normal. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 value for male and female rabbits was > 3160 mg/kg bw.
- Executive summary:
In this older study one or two New Zealand Albino rabbits (m or f) in each dosing group were dosed with undiluted TS at doses of 1000, 2000, 3160, 5010 or 7940 mg/kg bw over 24 hrs. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically. The dermal LD50 value for male and female rabbits was given with > 3160 mg/kg bw. Toxic signs included reduced appetite and activity, increasing weakness, collapse and death. In decedents, haemorrhagic areas of the lungs, liver hyperaemia, enlarged gall bladder and GI tract inflammation were noted, while in survivors viscera appeared normal.
This is the lowest value, as the other study give a higher one (13700 mg/kg)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 160 mg/kg bw
Additional information
Oral:
In a study, mixed groups of 5 male and female Sprague-Dawley strain albino rats were dosed via gavage with undiluted TS at doses of 3160, 3980, 5010 or 6310 mg/kg bw. The oral LD50 value for male and female rats was given with 3900 mg/kg bw. Toxic signs included reduced appetite and activity, increasing weakness, collapse and death. In decedents, haemorrhagic areas of the lungs, liver discoloration and acute GI tract inflammation were noted, while in survivors viscera appeared normal.
Dermal:
In this study, one or two New Zealand Albino rabbits (m or f) in each dosing group were dosed with undiluted TS at doses of 1000, 2000, 3160, 5010 or 7940 mg/kg bw over 24 hrs. Observations were made for toxic signs and the viscera of the test animals were examined macroscopically. The dermal LD50 value for male and female rabbits was given with > 3160 mg/kg bw. Toxic signs included reduced appetite and activity, increasing weakness, collapse and death. In decedents, haemorrhagic areas of the lungs, liver hyperaemia, enlarged gall bladder and GI tract inflammation were noted, while in survivors viscera appeared normal.
Inhalation:
In this study 6 male Sprague-Dawley strain albino rats were exposed to 2100 mg TS/m3 (whole body) over 6 hrs. None of the animals died and the viscera appeared normal 14 days after dosing. This correspond to CL0 / 4h > 3,15 mg/kg and certainly to a CL50 > 5 mg/L mist with dermal exposure.
Justification for classification or non-classification
The data availaible with DIPB do not warrant a classification for acute toxicity according to UN/EU GHS classification criteria.
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