Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
experimental determination not feasible (mixture); individual components expected to be ionised in the environmental pH range (4 – 9) based on the presence of acidic (pKa ~ 4) and basic (pKa ~ 10) functional groups in the respective structures (QSAR, Marvin Sketch)
Key value for chemical safety assessment
Additional information
It is not technically feasible to experimentally determine the dissociation constants of DOPA-Glycinate due to the material being a mixture of a number of soluble components.It should also be noted that OECD guideline number 112 only applies to active substances if the water solubility cannot be measured.
The components making up the substance are assumed to be ionised in the environmental pH range (4 – 9) based on the presence of acidic (pKa ~ 4) and basic (pKa ~ 10) functional groups in the respective structures.
This is confirmed by the provision of pKa values for the indivdual components of DOPA-Glycinate using QSAR (generated by MarvinSketch).
Overall, based on the properties, dissociation is not relevant under practical conditions, since at neutral, environmental and physiological pH conditions, >90% of the constituents should be in the ionic form.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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