Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: similar to OECD TG 401: LD50 1850 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 850 mg/kg bw
Quality of whole database:
The acute oral toxicity result is of sufficient quality and adequate for this dossier.

Additional information

Acute oral toxicity:

In an acute oral toxicity study performed similar to OECD 401 (pre-OECD and GLP), 10 rats were administered the test substance orally at dose levels of670, 1310, 2560 or 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Mortality was observed at the three highest dose levels. One, eight and ten animals died, all on the first day, in the dose groups 1310, 2560, and 5000 mg/kg bw, respectively. Clinical signs included lethargy, labored breathing, loss of righting reflex and coma.The acute oral LD50 for the test substance in rats was determined to be 1850 mg/kg bw.

Acute dermal toxicity:

In an acute dermal toxicity study, which was performed similar to OECD 402, 10 rabbits received a dermal application of 5000 mg/kg bw of the test material and were observed for 14 days. The dermal LD50 exceeded 5000 mg/kg bw.

Justification for classification or non-classification

The substance has to be classified as Acute Tox. 4 (H302) in accordance with EU CLP (EC 1272/2008 and its amendments).