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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May-October 2014
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 850.1300 (Daphnid Chronic Toxicity Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Vehicle:
yes
Test organisms (species):
Daphnia magna
Test type:
flow-through
Water media type:
freshwater
Limit test:
no
Total exposure duration:
21 d
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
21 µg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
21 µg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
21 µg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
growth
Validity criteria fulfilled:
yes
Conclusions:
The cladoceran, Daphnia magna, was exposed to Fyrolflex RDP at mean measured
concentrations of 0.99 to 21 μg/L under flow-through conditions for 21 days. There were no
statistically significant treatment-related effects on survival, reproduction or growth at any of the
concentrations tested. Consequently, the NOEC was 21 μg/L. The LOEC was >21 μg/L and the
MATC could not be calculated. The 21-day EC50 value for adult immobility and reproduction was
>21 μg/L, the highest concentration tested.
Executive summary:

The cladoceran, Daphnia magna, was exposed to Fyrolflex RDP at mean measured

concentrations of 0.99 to 21 μg/L under flow-through conditions for 21 days. There were no

statistically significant treatment-related effects on survival, reproduction or growth at any of the

concentrations tested. Consequently, the NOEC was 21 μg/L. The LOEC was >21 μg/L and the

MATC could not be calculated. The 21-day EC50 value for adult immobility and reproduction was

>21 μg/L, the highest concentration tested.

Description of key information

Two studies were performed. In a key study according to OECD guideline 211 under GLP, The chronic toxicity (21d-NOEC for reproduction) of Fyrolflex RDP towards Daphnia magna based on measured concentrations was found to be 0.021 mg/l. In the second study lower concentrations were investigated. These concentrations are at the level of the actually water solubility value of the substance. the value of NOEC 21 ug/L was found, this value is higher than the water solubility value of the substance. Both studies provides the same NOEC value of 21 ug/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
21 µg/L

Additional information