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EC number: 701-337-2 | CAS number: -
A sample of CR 733-S was tested in the rabbit acute eye irritation/corrosion test, performed according to OECD Guideline 405, 1987. Instillation of 0.1 ml of the test substance in one of the eyes of each of three albino rabbits resulted in adverse effects to the conjunctivae only. Approximately 60 min. after exposure, one animal showed slight reddening of the eyelids and slight chemosis, which resolved within 24 hours. No other adverse eye effects were observed in the treated animals, except for slight lacrimation on day 0.
Based on the estimated Draize score (1944) of 3.3 (60 min), the test substance should be classified as minimally irritating according to the scheme of Kay and Calandra (1962).
According to the criteria laid down in Annex VI of the EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC), and outlined in 1272/2008/EC (CLP/EU-GHS), the test substance need not be labelled as an eye irritant.
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