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EC number: 701-337-2 | CAS number: -
A Guinea Pig Maximisation Test (GPMT) was performed to determine the sensitising potential of the test substance, in accordance with OECD guideline 406 and under GLP conditions. 30 female Dunkin-Hartley guinea pigs were used. Intradermal induction was done with a 2.5% test substance solution (in propylene glycol), undiluted test article was used for epicutaneous induction. First challenge was done with undiluted test article and 25% and 10% solution, second challenge with 100% test article only (in duplo).
No positive skin reactions were noted after the induction phase in both the test article and control groups. After first challenge, a significant amount of animals were find to have positive skin reactions at the 25% and 10% concentration, but not with the undiluted test article. Therefore, a second challenge with the undiluted test article (100%) was done (in duplo). No clear positive reactions were noted in the test article or control group after the second challenge. It is concluded that RDP is not a skin sensitiser.
Based on the available information, RDP does not have to be classified according to the criteria laid down in Annex VI of the EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC), and outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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