Registration Dossier

Environmental fate & pathways

Biodegradation in water: screening tests

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
biodegradation in water: screening test, other
Remarks:
Pathway modelling and biodegradability assessment
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
June 09, 2020
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Qualifier:
no guideline followed
Principles of method if other than guideline:
enviPath that is both a database and a prediction system for the microbial biotransformation of organic environmental contaminants. The database provides the possibility to store and view experimentally observed biotransformation pathways. The pathway prediction system provides different relative reasoning models to predict likely biotransformation pathways and products.
enviPath is a complete redesign and reimplementation of UM-BBD/PPS (University of Minnesota Biocatalysis/Biodegradation Database and Pathway Prediction System).
The UM-BBD/PPS was recently transferred to Eawag and renamed to EAWAG-BBD/PPS, available at http://eawag-bbd.ethz.ch/index.html. The system has been completely redesigned, reimplemented and therefore renamed enviPath (https://envipath.org/).
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Value:
0.66
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
BIOWIN2
Parameter:
calculated rating of total degradation time (QSAR/QSPR)
Value:
2.83
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction
Remarks:
BIOWIN3, Weeks
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Value:
0.09
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction
Remarks:
BIOWIN6
Details on results:
The above results refer only to the test material. A more detailed biodegradation analysis, including the identified degradation products, is available in the attached full study report.
Validity criteria fulfilled:
yes
Interpretation of results:
inherently biodegradable
Conclusions:
Modelling of possible biodegradation pathways estimated by enviPath, according to the biotransformation rules, indicates that aerobic degradation of 1,2,3,6-tetrahydro-3-methylphthalic anhydride is likely; the degradation products were identified until two transformation levels.
All these substances were subjected to a Biodegradation screening assessment, according to the EPA BIOWIN 4.10 model.
According to the evaluation criteria set in the ECHA Guidances Chapters R.7b and R.11, 1,2,3,6-tetrahydro-3-methylphthalic anhydride was estimated as being inherently biodegradable and not potentially P or vP to the environment.
Executive summary:

1,2,3,6-tetrahydro-3-methylphthalic anhydride was estimated as being inherently biodegradable and not  potentially P or vP to the environment.

Description of key information

Primary degradation of the substance itself is rapid but significant ultimate degradation has not been demonstrated.

Modelling of possible biodegradation pathways estimated by enviPath, according to the biotransformation rules, indicates that aerobic degradation of 1,2,3,6-tetrahydro-3-methylphthalic anhydride is likely; the degradation products were identified until two transformation levels.

All these substances were subjected to a Biodegradation screening assessment, according to the EPA BIOWIN 4.10 model.

According to the evaluation criteria set in the ECHA Guidances Chapters R.7b and R.11, 1,2,3,6-tetrahydro-3-methylphthalic anhydride was estimated as being inherently biodegradable and not  potentially P or vP to the environment.

Key value for chemical safety assessment

Biodegradation in water:
inherently biodegradable

Additional information