Registration Dossier
Registration Dossier
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EC number: 226-247-6 | CAS number: 5333-84-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
There is no available information on animals. Several occupational sensitisation cases by inhalation at processing sites have been reported on tetrahydromethylphthalic anhydride (MTHPA), of which 3-MTHPA D4 is an isomer, which is classified due to human case reports and due to its chemical structure as skin sensitising cat.1 and respiratory sensitising cat.1 according to CLP (1272/2008/EC).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
There is no available information on animals. Two recommendations from Japanese and German commissions/societies are available, both concluding that tetrahydromethylphthalic anhydride (MTHPA) is sensitising to the respiratory tract.
- MTHPA was classified as "Sa", danger of sensitization of airways by the German MAK commission (Commission for the investigation of health hazards of chemical compounds in the work area). Substances classified as "Sa" can cause symptoms of the airways and also of the conjunctiva (substances causing airway sensitisation).
- The Japan society of occupational health has recommended 50 ug/m3 as a limit for exposure to MTHPA during an 8 hour work shift. The cause of this value was respiratory sensitisation.
There is no available information on animals. Several occupational sensitisation cases by inhalation at processing sites have been reported for tetrahydromethylphthalic anhydride (MTHPA), of which 3-MTHPA D is an isomer, which is classified due to human case reports and due to its chemical structure as skin sensitising cat.1 and respiratory sensitising cat.1 according to CLP (1272/2008/EC).
Justification for classification or non-classification
The substance is classified as skin sensitising cat.1 and respriatory sensitising cat.1 according to Regulation 1272/2008/EC (CLP) and Xn, R42/43 (May cause sensitisation by inhalation and skin contact) according to Directive 67/548/EEC (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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