Registration Dossier
Registration Dossier
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EC number: 952-252-4 | CAS number: -
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
The registered substance is an Alkyl phosphate and stearyl amine salts (EC = 952-252-4), mainly composed by primary alkylamines (CAS 90640-32-7, UVCB) and phosphoric acid, octadecyl ester (CAS 39471-52-8, Multi-Constituent). Both elements present a long hydrogenated (saturated) carbon chain combinaison mono/diester phosphate with primary amine (16 to 18 carbon atoms).
Terrestrial toxicity data are available for equivalent chain length alylamine and it is appropriate to use these data by a read-across approach for the registered substance.
Indeed, the presence of Phosphoric acid, octadecyl ester has no effects on earthworms mortality and reproduction, the 56d-NOEC = 1 000 mg/kg soil dw.
A NOEC reproduction of 200 mg/kg soil (dw) has been observed for hydrogenated tallow alkyl amine according to a TG OECD 222 and GLP study.
These data have been used as read-across for the registered substance. They are then converted to the corresponding value of the salt, resulting to a NOEC of 540 mg/kg soil (MW of Amines, hydrogenated tallow = 263, MW of the registered substance = 710,7 g/mol (256 g/mol Primary alkylamine salt + 454,7 g/mol Phosphoric acid, octadecyl ester)).
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 540 mg/kg soil dw
Additional information
Earthworm long-term toxicity for primary alkylamines
The effects of amines, hydrogenated tallow (CAS 61788-45-2) on mortality, biomass and reproduction of Eisenia fetida were tested according to OECD 222 under a static exposure for 56 days (Noack, 2006). Natural soil (Lufa 2.2) was used as substrate, and the different concentration of the substance mixed with the substrate. The concentrations applied were 50, 100, 200, 500, and 1,000 mg/kg soil dry weight. In addition tests using control and vehicle control were performed.
The test is valid without restrictions and the results are reliable. After 28 days of exposure, no effects on survival of the adult worms were observed in all concentrations. After the following four weeks, the reproduction rate (average number of juveniles) was significantly reduced in the concentrations of 500 and 1,000 mg/kg soil compared to the control. Hence, the LOEC is 500 mg/kg soil and the NOEC 200 mg/kg soil. This NOEC can be used as a chronic endpoint representing heterotrophs (consumer) in the terrestrial environment.
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