Registration Dossier
Registration Dossier
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EC number: 900-021-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 104 Days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- EC Number:
- 900-021-3
- Molecular formula:
- 3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) :C20 H22O5, 3,5-Heptanedione-1,7 -bis(4-hydroxyphenyl) : C19H20O4, 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl) : C21H24O6
- IUPAC Name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- Test material form:
- solid: crystalline
Constituent 1
In vitro test system
- Test system:
- other: Semi-Occlusive
- Source species:
- rabbit
- Cell type:
- other: Semi-Occlusive
- Cell source:
- foreskin from a single donor
- Source strain:
- New Zealand White
- Vehicle:
- water
- Control samples:
- not specified
- Amount/concentration applied:
- 0.5g
- Duration of treatment / exposure:
- 4h
- Duration of post-treatment incubation (if applicable):
- 48h
- Number of replicates:
- 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- In-vitro Skin Irritation/ Corrosion confirms that Substance is considered as non-Irritation.
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