Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Data source

Reference
Reference Type:
other: QSAR model
Title:
VEGA in silico platform v.1.1.4
Year:
2017
Bibliographic source:
Daphnia Magna LC50 48h (EPA) 1.0.7

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl succinate
EC Number:
203-419-9
EC Name:
Dimethyl succinate
Cas Number:
106-65-0
Molecular formula:
C6H10O4
IUPAC Name:
dimethyl succinate
Specific details on test material used for the study:
COC(=O)CCC(=O)OC

Test organisms

Test organisms (species):
Daphnia magna

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
94.68 mg/L
Remarks on result:
other: Substance predicted with VEGA Daphnia Magna EPA

Any other information on results incl. tables

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Applicant's summary and conclusion

Validity criteria fulfilled:
no
Conclusions:
The Daphnia Magna LC50 of the substance was predicted to be 94.68 mg/L.