Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Endpoint summary
Administrative data
Description of key information
Overall, the substance has an acute oral LD50 of about 5000 mg/kg bw.
The substance has a inhalation RD50 of 1600 mg/m3.
The substance has an acute dermal LD50 of > 5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 5 animals per sex
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 5 000 mg/kg bw
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The substance has a LD50 which falls between 500 and 5000 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The substance has a oral LD50 > 5000 mg/kg.
Referenceopen allclose all
500 mg/kg body weight: + 0/10; kidney changes (dilated renal pelvis, discoloration, tan nodules).
5000 mg/kg body weight: + 10/10; lethargy; rales (only 1 ♀); died animals: lungs: discoloration and oedema
5000 mg/kg body weight: + 0/10; lethargy; 2 animals with rales, 2 animals with discoloration of the lungs and dilated renal pelvis.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- mouse
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- other: RD50
- Remarks:
- exposure concentration producing a 50% respiratory rate decrease
- Effect level:
- 1 600 mg/m³ air
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The substance has a RD50 of 1600 mg/m3 in mouse.
Reference
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rabbit
- Sex:
- male/female
- Type of coverage:
- not specified
- Vehicle:
- not specified
- No. of animals per sex per dose:
- 5 animals per sex
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance has a dermal LD50 > 5000 mg/kg bw.
Reference
5000 mg/kg body weight: + 0/10; 2 animals in 1. or 2nd week: body weight ↓
Additional information
Justification for classification or non-classification
According to CLP Regulation, the substance has not to be classified for acute oral/inhalation/dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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