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Diss Factsheets

Administrative data

Endpoint:
fertility, other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Dicarboxylic acid (C4–C6) dimethylester, mixture (dimethyl succinate, dimethyl adipate, dimethyl glutarate and their mixture)
Year:
2007
Bibliographic source:
The MAK-Collection for Occupational Health and Safety

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl succinate
EC Number:
203-419-9
EC Name:
Dimethyl succinate
Cas Number:
106-65-0
Molecular formula:
C6H10O4
IUPAC Name:
dimethyl succinate

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Duration of treatment / exposure:
90 days exposure
Doses / concentrations
Dose / conc.:
400 mg/m³ air

Results and discussion

Any other information on results incl. tables

No adverse, substance-related effects on the reproductive organs were observed. Changes in individual hormone parameters and increased epididymal sperm counts were evaluated by the authors as unclear or as not assignable due to the high variability of the data and the relatively low number of animals/group and sex.

Applicant's summary and conclusion

Conclusions:
Under the test conditions, no adverse substance-related effects on the reproductive organs were observed.