Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across: supporting information
Preliminary study:
There were no daeths or clinical signs of toxicity. Based on this information, a dose level of 2000 mg/kg body weight was selected for the main study.
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
There were no deaths
Clinical signs:
No signs of systemic toxicity were noted during the study.
Body weight:
All animals showed an expected gain in body weight during the study.
Gross pathology:
No abnormalities were noted at necropsy.
Other findings:
no
Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral median lethal dose of titanium dioxide was found to be greater than 2000 mg/kg body weight. Based on these results, it is predicted that also no symbol and risk phrase are required for the structural analogue Titanium oxide (Ti3O5) according to EU labelling regulations.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification