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EC number: 946-248-1 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: EPA-821-R-02-013 : Short-Term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms
- Version / remarks:
- October, 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM Method E729
- Version / remarks:
- 1997
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- Sinodor
Citronellyl 3-methyl-2-butenoate
CAS No. 20770-40-5 - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- Propylene Glycol was used as vehicle.
- Details on test solutions:
- A range-finding toxicity test was conducted initially on the test material at three times the estimated water solubility to determine the test concentrations for the definitive chronic toxicity test.
Each test was also initiated with an uncontaminated laboratory water control and solvent control. The stock solution used for the test solution were prepared by diluting a known weight (grams) of the test material to a known volume. Propylene glycol was used as the solvent carrier for the test material. - Test organisms (species):
- Ceriodaphnia dubia
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Hardness:
- 80 - 100 mg/L as CaCO3
- Nominal and measured concentrations:
- The chronic toxicity test was initiated using three times the estimated water solubility as the highest test concentration and a dilution factor of 0.5 to produce six test concentrations. Each test was also initiated with an uncontaminated laboratory water control and solvent control.
Nominal test concentrations tested were :
0.79 mg/L
0.4 mg/L
0.2 mg/L
0.1 mg/L
0.05 mg/L
0.025 mg/L
Control
Solvent Control. - Details on test conditions:
- Propylene glycol was used as the solvent carrier for the test material. Moderately hard (80-100 mg/L CaCO3) dilute mineral water (DMW) was used as the laboratory control and dilution water for the chronic test.
- Key result
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 7 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.79 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- A chronic toxicity test was conducted with Ceriodaphnia dubia to determine the No Observed Effect Concentration (NOEC) for survival and reproduction, the Lowest Observed Effect Concentration (LOEC) for survival and reproduction and median lethal toxicant concentrations (LC50) of the test material.
NOEC Reproduction = 0.10 mg/L
LOEC Reproduction = 0.20 mg/L
NOEC Survival = 0.40 mg/L
LC50 > 0.79 mg/L - Executive summary:
A chronic toxicity test was conducted with Ceriodaphnia dubia to determine the No Observed Effect Concentration (NOEC) for survival and reproduction, the Lowest Observed Effect Concentration (LOEC) for survival and reproduction and median lethal toxicant concentrations (LC50) of the test material.
NOEC Reproduction = 0.10 mg/L
LOEC Reproduction = 0.20 mg/L
NOEC Survival = 0.40 mg/L
LC50 > 0.79 mg/L.
Reference
Description of key information
A chronic toxicity test was conducted with Ceriodaphnia dubia to determine the No Observed Effect Concentration (NOEC) for survival and reproduction, the Lowest Observed Effect Concentration (LOEC) for survival and reproduction and median lethal toxicant concentrations (LC50) of the test material.
NOEC Reproduction = 0.10 mg/L
LOEC Reproduction = 0.20 mg/L
NOEC Survival = 0.40 mg/L
LC50 > 0.79 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.1 mg/L
Additional information
A chronic toxicity test was conducted with Ceriodaphnia dubia to determine the No Observed Effect Concentration (NOEC) for survival and reproduction, the Lowest Observed Effect Concentration (LOEC) for survival and reproduction and median lethal toxicant concentrations (LC50) of the test material.
NOEC Reproduction = 0.10 mg/L
LOEC Reproduction = 0.20 mg/L
NOEC Survival = 0.40 mg/L
LC50 > 0.79 mg/L
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