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EC number: 946-248-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
LD50 oral rats > 10ml/kg (similar to OECD 401)
LD50 dermal rabbits > 5000mg/kg (based on the worst case of a one-to-one read across and confirmed by an OECD QSAR Toolbox prediction)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- After some preliminary observations, the test material was given undiluted, by gavage to groups of five males and five females, in one single dose of 10.0 ml per kg body weight.
After treatment the rats received stock diet and tap water as libitum.
They were observed for signs of intication during 14 day period, after which autopsies were carried out on the survivors. - GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Specific details on test material used for the study:
- A 50 ml sample of the test material was received from the principal in January 1978. It was a colourless liquid with a pugent odour, designated Sinodor 688 and coded M-76-193.
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Young adult albino rats (wistar-derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult albino rats (Wistar-derived) from the Institue's colony were used. The body weights of males varied from 209 to 248g, those of females from 145 to 186g. The rats were housed in groups of five in screen-bottomed stainless steel cages, in a well-ventilated room, maintained at 23-25°C. Before dosing the rats were fasted overnight.
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- After some preliminary observations, the test material was given undiluted, by gavage to groups of five males and five females, in one single dose of 10.0 ml per kg body weight.
- Doses:
- 10.0 ml per kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- After some preliminary observations, the test material was given undiluted, by gavage to groups of five males and five females, in one single dose of 10.0 ml per kg body weight. Due to the small quantity of the test material, no higher doses could be given. After treatment the rats received stock diet and tap water ad libitum. They were observed for signs of intoxication during a 14 day period, after which autopsies were carried out on the survivors.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No deaths
- Mortality:
- No deaths occured
- Clinical signs:
- other: Within a few hours after dosing the rats showed signs of sluggishness and decreased activity. Later on the rats recovered and looked quite healthy during the remaining part of the observation period. Macroscopic examination of the survivors at autopsy r
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- From these results it appears that the oral LD50 of Sinodor exceeds 10 ml per kg body weight.
- Executive summary:
Acute oral toxicity was determined with a method similar to OECD Guideline 401.
At a dose of 10 ml/kg body weight, no deaths occured and clinical signs a few hours after dosing were that the rats showed signs of sluggishness and decreased activity.
Later on the rats recovered and looked quite healthy during the remaining part of the observation period. Macroscopic examination of the survivors at autopsy revealed no treatment related gross alterations.
From these results it appears that the oral LD50 of Sinodor exceeds 10 ml per kg body weight, GHS criteria not met.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- A detailed read-across justification in-line with the ECHA RAAF guidelines is provided as an attached document.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured
- Clinical signs:
- other: Symptomatology: none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 dermal in rats expected to be above 5000 mg/kg.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1975
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10 animals (sex not specified)
- Control animals:
- no
- Details on study design:
- Not specified
- Key result
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured
- Clinical signs:
- other: Symptomatology: none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on this study, acute dermal LD50 for Citronellyl crotonate is > 5 000 mg/kg. No classification required.
- Executive summary:
Ten rabbits were administered 5 g/kg of the test material, and the animals were observed for mortality and clinical signs for 14 days. No deaths or effects observed so acute dermal LD50 > 5g/kg. No classification required.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Acute Oral Toxicity Study:
Acute oral toxicity was determined with a method similar to OECD Guideline 401.
At a dose of 10 ml/kg body weight, no deaths occured and clinical signs a few hours after dosing were that the rats showed signs of sluggishness and decreased activity.
Later on the rats recovered and looked quite healthy during the remaining part of the observation period. Macroscopic examination of the survivors at autopsy revealed no treatment related gross alterations.
From these results it appears that the oral LD50 of Sinodor exceeds 10 ml per kg body weight, GHS criteria not met.
Acute Dermal Toxicity Study:
Ten rabbits were administered 5 g/kg of the test material, and the animals were observed for mortality and clinical signs for 14 days. No deaths or effects observed so acute dermal LD50 > 5g/kg. No classification required.
An OECD QSAR Toolbox analysis was performed for this endpoint and predicted an LD50 above 10g/kg, confirming the above selected one-to-one read-across.
Justification for classification or non-classification
Based on the data available and key results described in this summary, the substance has shown no acute systemic toxicity potential and should therefore not be classified for acute toxicity according to the (EC) No 1272/2008 Regulation (CLP).
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