Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 April 2004 - 06 August 2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5-methylresorcinol
EC Number:
207-984-2
EC Name:
5-methylresorcinol
Cas Number:
504-15-4
Molecular formula:
C7H8O2
IUPAC Name:
5-methylbenzene-1,3-diol
Constituent 2
Chemical structure
Reference substance name:
Resorcinol
EC Number:
203-585-2
EC Name:
Resorcinol
Cas Number:
108-46-3
Molecular formula:
C6H6O2
IUPAC Name:
benzene-1,3-diol
Constituent 3
Chemical structure
Reference substance name:
2,5-dimethylresorcinol
EC Number:
207-688-3
EC Name:
2,5-dimethylresorcinol
Cas Number:
488-87-9
Molecular formula:
C8H10O2
IUPAC Name:
2,5-dimethylbenzene-1,3-diol
Constituent 4
Chemical structure
Reference substance name:
2-methylresorcinol
EC Number:
210-155-8
EC Name:
2-methylresorcinol
Cas Number:
608-25-3
Molecular formula:
C7H8O2
IUPAC Name:
2-methylbenzene-1,3-diol
Constituent 5
Chemical structure
Reference substance name:
4-methylresorcinol
EC Number:
207-827-8
EC Name:
4-methylresorcinol
Cas Number:
496-73-1
Molecular formula:
C7H8O2
IUPAC Name:
4-methylbenzene-1,3-diol
Constituent 6
Chemical structure
Reference substance name:
4,5-dimethylbenzene-1,3-diol
EC Number:
610-895-5
Cas Number:
527-55-9
Molecular formula:
C8H10O2
IUPAC Name:
4,5-dimethylbenzene-1,3-diol
Constituent 7
Chemical structure
Reference substance name:
5-ethylbenzene-1,3-diol
Cas Number:
4299-72-3
Molecular formula:
C8H10O2
IUPAC Name:
5-ethylbenzene-1,3-diol
Constituent 8
Chemical structure
Reference substance name:
2-ethyl-5-methylbenzene-1,3-diol
Cas Number:
27465-63-0
Molecular formula:
C9H12O2
IUPAC Name:
2-ethyl-5-methylbenzene-1,3-diol
Constituent 9
Chemical structure
Reference substance name:
5-ethyl-2-methylbenzene-1,3-diol
Cas Number:
34745-52-3
Molecular formula:
C9H12O2
IUPAC Name:
5-ethyl-2-methylbenzene-1,3-diol
Constituent 10
Chemical structure
Reference substance name:
2,4,5-trimethylbenzene-1,3-diol
Cas Number:
20427-81-0
Molecular formula:
C9H12O2
IUPAC Name:
2,4,5-trimethylbenzene-1,3-diol
Constituent 11
Chemical structure
Reference substance name:
2,4-dimethylresorcinol
EC Number:
211-213-5
EC Name:
2,4-dimethylresorcinol
Cas Number:
634-65-1
Molecular formula:
C8H10O2
IUPAC Name:
2,4-dimethylbenzene-1,3-diol
Constituent 12
Chemical structure
Reference substance name:
Phenol
EC Number:
203-632-7
EC Name:
Phenol
Cas Number:
108-95-2
Molecular formula:
C6H6O
IUPAC Name:
phenol
Constituent 13
Chemical structure
Reference substance name:
Cresol
EC Number:
215-293-2
EC Name:
Cresol
Cas Number:
1319-77-3
Molecular formula:
C7H8O
IUPAC Name:
cresol
Constituent 14
Reference substance name:
not applicable
Molecular formula:
not applicable
IUPAC Name:
not applicable
Test material form:
liquid
Details on test material:
Sponsor's identification: Total shale oil phenols
Description: dark brown extremely viscous liquiy
Batch number: Part No. 3
Date received: 30 January 2004
Storage conditions: room temperature, in the dark
Radiolabelling:
no

Study design

Analytical monitoring:
yes
Details on sampling:
Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 0.2 g/L in the three buffer sultions. A 1 % co-solvent of acetonitrile was used to aid solubility.
The solutions were shielded from light whilst maintained at the test temperature.
Buffers:
pH 4: Potassium hydrogen phthalate (5.0 mmol/L)

pH 7: Disodium hydrogen orthophosphate (4.0 mmol/L)
Potassium dihydrogen orthophosphat (2.0 mmol/L)
Sodium chloride (2.0 mmol/L)

pH 9: Disodium tetraborate (1.0 mmol/L)
Sodium chloride (2.0 mmol/L)
Duration of testopen allclose all
Duration:
120 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
ca. 0.201 g/L
Duration:
120 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
ca. 0.206 g/L
Duration:
168 h
pH:
11
Temp.:
50 °C
Initial conc. measured:
ca. 0.202 g/L

Results and discussion

Transformation products:
not measured
Total recovery of test substance (in %)open allclose all
% Recovery:
ca. 100
pH:
4
Temp.:
50 °C
Duration:
ca. 120 h
% Recovery:
ca. 100
pH:
7
Temp.:
50 °C
Duration:
ca. 120 h
% Recovery:
ca. 66.9
pH:
9
Temp.:
50 °C
Duration:
ca. 120 h
% Recovery:
ca. 67.4
pH:
9
Temp.:
50 °C
Duration:
ca. 168 h
Dissipation DT50 of parent compoundopen allclose all
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr

Applicant's summary and conclusion

Validity criteria fulfilled:
yes