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EC number: 222-468-7 | CAS number: 3483-12-3
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 January - 21 February 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- (R*,R*)-1,4-dimercaptobutane-2,3-diol
- EC Number:
- 222-468-7
- EC Name:
- (R*,R*)-1,4-dimercaptobutane-2,3-diol
- Cas Number:
- 3483-12-3
- Molecular formula:
- C4H10O2S2
- IUPAC Name:
- 1,4-disulfanylbutane-2,3-diol
Constituent 1
- Specific details on test material used for the study:
- Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 42.44 °C
- Atm. press.:
- >= 1 000.7 - <= 1 001.7 hPa
- Decomposition:
- no
Any other information on results incl. tables
During the heating phase a distinct endothermic effect was observed in the temperature range of 40 – 60°C, which can be assigned to the melting of the test item. As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 42.44°C, this temperature can be used as melting point. The test item has a melting point of 42.4 °C.
Results of the DSC-measurement
| No. | Sample weight/mg | Onset of Effect/°C | Range of Effect/°C | Weight loss/mg | Atmosperhic Presure/HPa |
| PN19051 | 8.91 | 42.28 271.83 |
40 – 60 (endo) 250 – 320 (endo) |
8.91 | 1000.7 |
| PN19053 | 8.35 | 42.60 269.71 |
40 – 60 (endo) 250 – 320 (endo) |
8.34 | 1001.7 |
Applicant's summary and conclusion
- Conclusions:
- The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
- Executive summary:
The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
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