Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the substance has no ionic structure
other:
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
In accordance with REACH Regulation (EC) No. 1907/2006 Annex IX, column 2 section 7.16 the study does not need to be conducted if it is scientifically not possible to perform the test: based on structural assessment and with consideration to relevant (Q)SAR models, the substance does not possess an ionisable functional group which may dissociate in the relevant pH range: pH 4 to 9 and/or does not possess a functional group with a pKa in the 0 to 14 range, as such determination appears technically not possible. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.17, July 2017) the study does not need to be conducted.

References:
1. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.17, July 2017)
2. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7b: Endpoint Specific Guidance, June 2017)
3. ECHA Guidance on Application on the CLP Criteria, (v5.0, July 2017)
4. ECHA Guidance on PBT/vPvB assessment (v3.0, June 2017)

Description of key information

Dissociation Constant: no relevant ionisable functional groups, no pKa in 0 to 14 range based on structural assessment

Key value for chemical safety assessment

Additional information

In accordance with REACH Regulation (EC) No. 1907/2006 Annex IX, column 2 section 7.16 the study does not need to be conducted if it is scientifically not possible to perform the test: based on structural assessment and with consideration to relevant (Q)SAR models, the substance does not possess an ionisable functional group which may dissociate in the relevant pH range: pH 5 to 9 and/or does not possess a functional group with a pKa in the 0 to 14 range, as such determination appears technically not possible. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.17, July 2017) the study does not need to be conducted.

References:

1. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.17, July 2017)

2. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7b: Endpoint Specific Guidance, June 2017)

3. ECHA Guidance on Application on the CLP Criteria, (v5.0, July 2017)

4. ECHA Guidance on PBT/vPvB assessment (v3.0, June 2017)