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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23-07-2019 to 13-08-2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Boiling pt.:
274 °C
Atm. press.:
1 010 hPa
Decomposition:
no
Remarks on result:
other: mean boiling point (n = 2); measurement under flow of nitrogen ; atmospheric pressure was 1010 hPa.

Main study

- Experiment 1: During cooling, an exothermic effect between -20°C and -40°C was observed, which was due to crystallization of the test item. During heating, an endothermic effect between -25°C and 0°C was observed, followed by another endothermic effect between 200°C and 300°C. The extrapolated onset temperature of the second effect was 273.622°C.

- Experiment 2: Was conducted to examine the second endothermic effect by using a higher heating rate of 50°C/minute. The first endothermic peak shifted to higher temperatures, whilst the second did not, demonstrating that evaporation of the test substance was the reason for the endothermic effect. Since a higher heating rate was used, the extrapolated onset temperature of the second endothermic effect was not used in the calculation of the boiling point.

- Experiment 3: Was conducted to further examine the boiling temperature of the test item in duplicate. An endothermic peak was observed. The extrapolated onset of the evaporation peak was 263.995°C. The difference in extrapolated onset between experiment 1 and 3 was >1°C, therefore the test item may have evaporated before boiling due to a lower sample amount.

- Experiment 4: Was conducted to further examine the boiling temperature of the test item as a duplicate of experiment 3. The experiment was conducted under the same conditions as experiment 4, but with a higher sample amount. The extrapolated onset of the boiling peak was 274.326°C.

The boiling temperature was determined as the mean boiling temperature of Experiment 1 (273.622°C) and Experiment 4 (274.326°C). The boiling temperature of the test item was 274.0°C (or 547.15K).

Conclusions:
The boiling temperature of the test item has been determined to be 274 °C (or 547 K).
Executive summary:

The boiling temperature was examined according to EU Method A.2 and OECD TG 103 using the Differential Scanning Calorimetry method under GLP. The guideline defines the standard boiling temperature as the temperature at which the vapour pressure of a liquid is the same as the standard pressure (i.e. 1013.25 hPa). The boiling temperature of the test item were determined as the mean boiling temperature obtained from two experiments; from which the thermal events for each individual DSC-runs were within ±0.5°C of the determined mean. The mean boiling point was 274 °C (or 547 K).

Description of key information

Bp: 274 °C (or 547 K) at ca. 1 atmosphere pressure, EU Method A.2 - DSC method, 2019

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
274 °C

Additional information

Key study : EU Method A.2, 2019 : The boiling temperature was examined according to EU Method A.2 and OECD TG 103 using the Differential Scanning Calorimetry method under GLP. The guideline defines the standard boiling temperature as the temperature at which the vapour pressure of a liquid is the same as the standard pressure (i.e. 1013.25 hPa). The boiling temperature of the test item were determined as the mean boiling temperature obtained from two experiments; from which the thermal events for each individual DSC-runs were within ±0.5°C of the determined mean. The mean boiling point was 274 °C (or 547 K).