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Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

The substance is negative in the Ames test (similar to OECD TG 471).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

In vitro bacterial reverse mutation assay:

In this in vitro assessment of the mutagenic potential of the test substance conducted equivalent or similar to OECD TG 471 and in compliance with GLP, the ability of the test substance to induce mutations was investigated. For this purpose Salmonella typhimurium strains TA100, TA1535, TA98 and TA1537 and Escherichia coli strain WP2uvrA were used in a pre-incubation method in the presence and absence of a metabolic activation system (S9 mix).

As a result, the mutagenicity of the test substance was found to be negative because the numbers of revertant colonies in the test substance treatment groups were less than two times that in each negative control in all test strains with and without S9 mix. Therefore, it is concluded that the test substance has no ability to induce mutations under the present test conditions.

Similar reaction mass with EC no:949-569-5

This reaction mass containing the same two substances but different in concentration showed also a negative Ames test.

Justification for classification or non-classification

The substance does not need to be classified for mutagenicity according to EU CLP (EC No. 1272/2008 and its amendments).