Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-11-09 to 2009-11-19
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study done according to the respective OECD guideline; not under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
not specified
GLP compliance:
no
Type of method:
thermal analysis
Remarks:
Differential Scanning Calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-
EC Number:
806-756-5
Cas Number:
1262985-24-9
Molecular formula:
C24 H16 Br Cl2 F2 N3 O4 S
IUPAC Name:
1-Propanesulfonamide, N-[3-[[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-
Test material form:
other: solid
Details on test material:
white solid

Results and discussion

Melting / freezing point
Melting / freezing pt.:
209 °C
Atm. press.:
1 atm
Decomposition:
yes
Decomp. temp.:
265 °C

Any other information on results incl. tables

Endothermic range: 193 -219 °C and 194 -219 °C (duplicate samples)

Mean endothermic peak temperature 209 °C

Exothermic range: 219 -396 °C and 219 -398 °C

Mean exothermic peak temperature 265 °C

Applicant's summary and conclusion

Conclusions:
Melting point determined to be 209 °C based upon duplicate endothermic measurements.
Executive summary:

Method: The melting point was determined using Differential Scanning Calorimetry (DSC).

Results: Melting point determined to be 209 °C based upon duplicate endothermic measurements.