3-({-[(4-Carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid ethyl ester hydrochloride

Guidance on Safe Use

First-aid measures

Skin contact: take off contaminated clothing, immediately wash skin with plenty of water. If there was no irritation, it is advisable to use soap. Consult a doctor, if disturbing symptoms occur.

Eye contact: consult a doctor if disturbing symptoms appear. Protect non- irritated eye, remove contact lenses. Rinse the irritated eye thoroughly with water for 10-15 minutes. Avoid strong stream of water - the risk of cornea damage.

Ingestion: do not induce vomiting. Call a doctor  and show container or label. If vomiting occurs spontaneously, keep head below hips to prevent aspiration. Never give anything by mouth to an unconscious person.

Inhalation: consult a doctor . Remove the victim to fresh air, keep warm and at rest. If the victim is unconscious, make sure that airways are not obstructed and place the victim in recovery position. Perform artificial respiration or give oxygen if needed.

Fire-fighting measures

Extinguishing media

      Use water spray to cool fire-exposed containers. Use water spray, dry chemicals, carbon dioxide, or chemical foam.

Special hazards arising from the substance or mixture - May produce toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride if burning.

Advice for firefighters The protective measures typical in case of fire. Do not stay in the danger zone without adequate fire-resistant clothing and chemical-contained breathing apparatus with independent air circulation

Accidental release measures

Personal precautions, protective equipment and emergency procedures: Limit the access for the outsiders into the breakdown area, until the suitable cleaning operations are completed. Ensure that the effects of breakdown are removed only by trained personnel. In case of large spills, isolate the affected area. Avoid direct contact with releasing product. Use personal protective equipment. Avoid contact with eyes and skin. Provide adequate ventilation.

Environmental precautions: Prevent  disposal directly to the aqueous environment and soil.

Methods and material for containment and cleaning up: Collect mechanically. Place the collected material in a labelled disposal bag/container. After removal wash the contaminated place with plenty of water and ventilate.

Handling and storage

General rules of occupational safety and hygiene should be followed. Avoid breathing dust. Do not allow for a contact with eyes, skin, clothing. Avoid prolonged or repeated exposure. Ensure a suitable ventilation system. Protect from contact with ignition sources.

Wash hands carefully after the contact with the substance. Do not eat or drink or smoke in the workplace. Separate the working clothes from the normal clothes.

Store in closed, original containers.

Protect from high temperature and strong oxidizing agents.

Secure measures to avoid contact with humidity or water.

In the storage area do not eat nor drink, do not smoke, do not use open fire or sparkling equipment.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

substance is not dangerous during transport

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

substance is not dangerous during transport

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

substance is not dangerous during transport

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

substance is not dangerous during transport

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Personal protection measures have to be in compliance with requirements from the Directive 89/686/WE (with later corrigendum). Employer is obliged to ensure proper protection means adequate to the activities conducted by the employees and which meet the quality requirements, are maintained and cleaned.

Hands protection: safety gloves

Gloves material should be impermeable and resistant to the product. The selection of the material should be done basing on the data: breakthrough time, penetration rate and degradation. Moreover, the selection of the proper gloves should take into account also the quality characteristics and the producer. The information about the breakthrough time should be received from the producer and followed by the users.

Skin protection: protective suit and boots. In each case, remove the dirty clothing. If there has been contact with the product of the whole body or parts thereof, immediately wash them.

Eye protection: dustproof safety goggles or face shield, designed to protect your eyes

Respiratory protection: disposable anti-dust mask FFP3 class or anti-dust full face or half face mask with filters P3 class.

Stability and reactivity

Chemical stability: stable under recommended storage conditions

Possibility of hazardous reactions:Hazardous Polymerization has not been reported

Conditions to avoid: sources of ignition, heat, incompatible material

Incompatible materials - Strong oxidizing agents, strong acids, strong bases.

Hazardous decomposition products - not known

Disposal considerations

Incineration - wastes formed at manufacturer/user site should be mixed with a combustible solvent and burnt in a chemical incinerator equipped with an afterburner and scrubber according to current site manufacturing/using regulations.

The release of substance to industrial sewerage system should be conducted in accordance with international, national, regional, state or local environmental control regulations and laws.

Packaging after product should be directed to the licensed disposal company.