Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Gross autopsy not reported, no information about GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- other: OECD SIDS
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- 10 male rats/concentration, head-only exposure, 6 concentrations, heated vapour was diluted with humidified and O2-enriched air and thus converted to a mixture of vapour and liquid aerosol, post exposure observation time: 14 days
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- Purity 99.8%
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male
Administration / exposure
- Route of administration:
- other: inhalation: mixture of vapour and liquid aerosol
- Type of inhalation exposure:
- head only
- Vehicle:
- other: humidified and O2-enriched air
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 1.56, 1.83, 2.46, 2.64, 3.23, 3.33 mg/L
- No. of animals per sex per dose:
- 10 male rats/concentration
- Control animals:
- no
- Statistics:
- LC50 value was calculated from statistically not significant regression (because mortality was not strictly dose-dependant).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3.2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 1.56 mg/L: 1 rat (day 5)
1.83 mg/L: 3 rats (2 on day 2, 1 on day 3)
2.46 mg/L: 2 rats (days 2 and 3)
2.64 mg/L: 10 rats (1 on day 0, 1 on day 1, 7 on day 2, 1 on day 3)
3.23 mg/L: 1 rat (day 2)
3.33 mg/L: 6 rats ( 1 on day 2, 2 on day 2, 2 on day 3, 1 on day 7) - Clinical signs:
- other: During exposure: slight to moderate cyanosis, semi-prostration, lethargy and reddish brown nasal discharge to 24 hours, slight to moderate corneal opacity, tachypnea, some rats with partial hind-leg paralysis, abnormal arched-back posture. Post exposure:
- Body weight:
- Weight loss of 8 to 16% from 1 to 3 days with normal gains thereafter.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
