Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-854-9 | CAS number: 88-73-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on purity, no individual pathologic data.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- other: OECD SIDS
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- 2 rabbits/sex/dose, 5 doses, single dermal application (intact skin), undiluted (warmed to make suitable for dosing), no further information, exposure time: 24 hours, post-exposure observation time: 14 days.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- No data on purity.
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: undiluted, warmed to make suitable for dosing
- Details on dermal exposure:
- TEST SITE
- Intact skin
REMOVAL OF TEST SUBSTANCE
- No data
TEST MATERIAL
- Undiluted, warmed to make suitable for dosing - Duration of exposure:
- 24 hours
- Doses:
- 251, 316, 398, 501, 631 mg/kg bw
- No. of animals per sex per dose:
- 2 rabbits/sex/dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 445 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 355 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Males: 0, 0, 0, 2, and 2 animals died at 251, 316, 398, 501 and 631 mg/kg bw, respectively.
Females: 0, 1, 2, 1, and 2 animals died at 251, 316, 398, 501 and 631 mg/kg bw, respectively.
Time of death: no data. - Clinical signs:
- Lethargy (lasting up to 3 days), increasing weakness, collapse.
- Gross pathology:
- Decedents: haemorrhagic areas of the lungs; discoloration of liver, kidney and spleen; enlarged gall bladder; gastrointestinal inflammation.
Survivors: viscera appeared normal.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
