Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test method no longer in use, incompletely documented, and no data on purity.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 973
- Reference Type:
- other: OECD SIDS
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Principles of method if other than guideline:
- 3 drops (10% sol.) were applied to the clipped area of the skin of 10 guinea pigs; on day 22 injection of Freund-adjuvans and test substance into the hind paw (0.5 mg/kg bw) was performed, on day 28 3 drops (10 % sol.)were applied to an untreated clipped area of the skin. The reading times are not mentiond.
- GLP compliance:
- no
- Type of study:
- other: modified Freund's complete adjuvant test
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: 10% (epicutaneous), 0.5 mg/kg bw (intradermal)
Challenge: 10%
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: 10% (epicutaneous), 0.5 mg/kg bw (intradermal)
Challenge: 10%
- No. of animals per dose:
- 10
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: reading time not mentioned
- Clinical observations:
- sensitising
- Remarks on result:
- other: Reading: other: reading time not mentioned. Clinical observations: sensitising.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
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