Registration Dossier
Registration Dossier
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EC number: 600-496-4 | CAS number: 103877-51-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Internationally accepted method, EPI-Suite, EPA (USA)
- Justification for type of information:
- See attached the QMRF and QPRF for the QSAR model
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.
- Specific details on test material used for the study:
- SMILES: CCOC(=O)C1=CN(c2c(C1(=O))ccc(c2C)CL)C3CC3
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- other: not readily biodegradable based on QSAR/QSPR prediction
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test substance was predicted to be not ready biodegradable (EPI-Suite, BIOWIN v4.10).
- Executive summary:
The test substance was predicted to be not ready biodegradable (EPI-Suite, BIOWIN v4.10).
Reference
BIOWIN1 (Linear Model): 0.4500
BIOWIN2 (Non-Linear Model): 0.2030
Expert Survey Biodegradation Results:
BIOWIN3 (Ultimate Survey Model): 2.1050 (months)
BIOWIN4 (Primary Survey Model): 3.0915 (weeks)
MITI Biodegradation Probability:
BIOWIN5 (MITI Linear Model): 0.2489
BIOWIN6 (MITI Non-Linear Model): 0.0314
Anaerobic Biodegradation Probability:
BIOWIN7 (Anaerobic Linear Model): -1.7514
Ready Biodegradability Prediction: NO
Description of key information
Key Study. Data from EPI-Suite, EPA (USA) / BIOWIN v4.10 calculation method. The test substance was predicted to be not ready biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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