Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
Principles of method if other than guideline:
In vitro test for corrosivity on reconstructed human epidermis EST-1000.
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(difluoromethyl)-1-methyl-1 H-pyrazole-4-carbonyl chloride
EC Number:
619-511-0
Cas Number:
141573-96-8
Molecular formula:
C6H5ClF2N2O
IUPAC Name:
3-(difluoromethyl)-1-methyl-1 H-pyrazole-4-carbonyl chloride

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
% tissue viability
Remarks:
mean value of 3 tissues
Run / experiment:
3 min exposure
Value:
73.58
Vehicle controls validity:
valid
Negative controls validity:
not examined
Positive controls validity:
valid
Remarks:
The reliability of the test method was confirmed prior to the experimental study by interlaboratory validation.
Irritation / corrosion parameter:
% tissue viability
Remarks:
mean value of 3 tissues
Run / experiment:
60 min exposure
Value:
1.51
Vehicle controls validity:
valid
Negative controls validity:
not examined
Positive controls validity:
valid
Remarks:
The reliability of the test method was confirmed prior to the experimental study by interlaboratory validation.

Any other information on results incl. tables

No scores on irritation parameters can be provided, as the study is an in vitro study using reconstructed human epidermis.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information

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