Registration Dossier
Registration Dossier
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EC number: 931-371-5 | CAS number: 171171-80-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The test material was non-mutagenic in bacteria and did not induce chromosome damage in human peripheral blood lymphocytes. Those data were supported by a structurally similar substance, which failed to cause gene mutation in mouse lymphoma cells.
Short description of key information:
Negative for mutagenic effect on bacteria (OECD 471).
Negative for induction of structural and numerical chromosome aberrations (OECD 473).
Behaviour of a close chemical analogue strongly predicts the substance will be negative for gene mutation in mouse lymphoma cells (OECD 476).
Endpoint Conclusion: No adverse effect observed (negative)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
An in vivo micronucleus study was conducted in the read-across analogue substance EC No 931-276-9, for notification in another region. The study can be used for the registration substance. The results of the test were negative, and support the in vitro conclusions.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
The test substance does not meet criteria for classification under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008.
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