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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23.-24.10.2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
European Commission Regulations (EC) No. 440/2008 and No. 761/2009,
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: Knudsen cell
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
< 0 hPa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
< 0 hPa
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
< 0 hPa

The vapour pressure was measured in the temperature range of 50 °C to 120 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1. After the measurement the test item remained visually unchanged. No mass loss occurred.

 

See table 1 for individual results.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature /°C

Vapour pressure / hPa

50

n.e.

70

n.e.

80

n.e.

90

n.e.

100

n.e.

110

n.e.

120

n.e.

 

All measured vapour pressures were below the detection limit of 10-5hPa.

 

For an extrapolation to lower temperatures the Antoine equation was used.

T/°C

p/hPa

p/Pa

20

<4.6x10-10

<4.6x10-8

25

<8.9x10-10

<8.9x10-8

50

<1.8x10-8

<1.8x10-6

Conclusions:
The vapour pressures of the test item at 20, 25 and 50 °C were extrapolated by using the Antoine constants with following results: <4.6x10-8Pa (20 °C), <8.9x10-8Pa (25 °C) and <1.8x10-6Pa (50 °C).
Executive summary:

A study was performed according to OECD TG 104 and Commission Regulation (EC) No. 440/2008, method A.4 in order to determine the vapour pressure of the test item by using the effusion method. The vapour pressure was measured by determining the boiling point of the test item at various specified pressures between about 10 and 1000 hPa. A constant temperature under constant pressure indicated that the boiling point was reached. Different vapour pressures were measured within the temperature range of 10 to 47 °C. The vapour pressures of the test item at 20, 25 and 50 °C were extrapolated by using the Antoine constants with following results: <4.6x10-8Pa (20 °C), <8.9x10-8Pa (25 °C) and <1.8x10-6Pa (50 °C).

Description of key information

The vapour pressure of the test item was determined to be <4.6x10-8Pa (20 °C), <8.9x10-8Pa (25 °C) and <1.8x10-6Pa (50 °C) using the effusion method.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

A study was performed according to OECD TG 104 and Commission Regulation (EC) No. 440/2008, method A.4 in order to determine the vapour pressure of the test item by using the effusion method. The vapour pressure was measured by determining the boiling point of the test item at various specified pressures between about 10 and 1000 hPa. A constant temperature under constant pressure indicated that the boiling point was reached. Different vapour pressures were measured within the temperature range of 10 to 47 °C. The vapour pressures of the test item at 20, 25 and 50 °C were extrapolated by using the Antoine constants with following results: <4.6x10-8Pa (20 °C), <8.9x10-8Pa (25 °C) and <1.8x10-6Pa (50 °C).