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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
5.3 - 6.6
Temp.:
35 °C
pH:
7
Conclusions:
log Pow= 5.3; 5.9* and 6.6*
* indicative values, peaks are outside calibration domain
Executive summary:

The Partition Coefficient n-octanol/water of GR-86-6599 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

 

The result is:

Partition coefficients n-octanol/water of GR-86-6599:     

log Pow= 5.3; 5.9* and 6.6*          

* indicative values, peaks are outside calibration domain

Description of key information

The Partition Coefficient n-octanol/water of GR-86-6599 was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

 

The result is:

Partition coefficients n-octanol/water of GR-86-6599:     

log Pow= 5.3; 5.9* and 6.6* 

* indicative values, peaks are outside calibration domain

Key value for chemical safety assessment

Log Kow (Log Pow):
5.3
at the temperature of:
35 °C

Additional information

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