Registration Dossier
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EC number: 203-996-7 | CAS number: 112-67-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound palmitoyl chloride: no data.
Hydrolysis product palmitic acid: With high probability acutely not harmful to algae within range of water solubility.
Hydrolysis product HCl: Acutely very toxic to aquatic algae.
Key value for chemical safety assessment
Additional information
Parent compound palmitoyl chloride (CAS 112 -67 -4):
No data on the toxicity of palmitoyl chloride are available. The substance rapidly decomposes in water and forms HCl (CAS 7647 -01 -0) and palmitic acid (CAS 57 -10 -3). Therefore, the short-term toxicity to algae is assessed on the basis of data on palmitic acid.
Hydrolysis product palmitic acid (CAS 57 -10 -3):
The toxicity of palmitic acid to algae is assessed via a study with the green alga Pseudokirchneriella subcapitata according to OECD 201 (NITE, 2000, report no.: NMMP/E99/1010). Solvent (HCO-50) was used to achieve the desired test concentrations. The 24-72 -h EC50 (growth rate) of > 0.9 mg/L (based on initially measured test concentrations) indicates that palmitic acid is not harmful to algae within the range of water solubility (WS = 0.04 mg/L, at 25 °C, Robb 1966, PhysProp database of EPI Suite v4.11). The 24 -72 -h NOEC was determined to be 0.9 mg/L (based on initially measured test concentrations). The measured concentrations were recalculated by NITE (Table: Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan (- March 2015)), resulting in a 72 -h ErC50 of > 0.6 mg/L and a 72 -h NOEC of 0.6 mg/L. Therefore, it can be concluded that palmitic acid is with high probability acutely not harmful to aquatic algae within range of water solubility.
Hydrolysis producthydrochloric acid (HCl; CAS 7647 -01 -0):
The hydrolysis product hydrochloric acid (HCl) was tested in an algae growth inhibition test according to OECD 201 with Pseudokirchneriella subcapitata. The 72-h ErC50 was 0.492 mg/L (acid equivalent to pH 5.3), the 72 -h NOEC was 0.097 (acid equivalent to pH 6; OECD 2002).
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