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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (B1)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: Rat(Sprague-Dawley)

Administration / exposure

Vehicle:
other: The test material was ground to a fine powder using a mortar and pestle, and freshly prepared as required, as a suspension at the appropriate concentration in 0.5% gum tragacanth.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Male: 200 mg/kg bw; Number of animals: 1; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 1; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Clinical signs of toxicity were hunched posture and pilo-
erection in two males and two females. The effects were
noted 1, 2 and 4 hours and 1, 2 and 3 days after treatment.


All animals showed expected gains in bodyweight over the
study period.
Gross pathology:
Effects on organs:
No abnormalities were noted at necropsy of animals killed
at the end of the study period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU

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