Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
3.4 micron

Test animals

Species:
other: Rat(Sprague-Dawley)

Administration / exposure

Vehicle:
other: Compressed air.
Details on inhalation exposure:
Dust aerosol atmosphere (nose only)
Duration of exposure:
4 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 2.08 mg/L air
Exp. duration:
4 h
Mortality:
Male: 2.08 mg/L; Number of animals: 2; Number of deaths: 0
Female: 2.08 mg/L; Number of animals: 2; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Occasional or isolated incidents of ptosis, pallor of the extremities and red/brown staining around the snout were also noted. Animals recovered to appear normal one or two days after exposure.
Gross pathology:
Effects on organs:
No abnormalities were detected at necropsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU

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