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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeClas tool
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: software
Title:
Unnamed
Year:
2020

Materials and methods

Principles of method if other than guideline:
Aquatic toxicity of pNMC oxide was determined by classifying based on Mixture rules from EU CLP (Tier 2 = additivity of soluble components (T/Dp data) to derive Hazard class) and back calculation to the corresponding EC10/NOEC range

Test material

impurity 1
Reference substance name:
Total unspecified impurities
IUPAC Name:
Total unspecified impurities
Constituent 1
Reference substance name:
Cobalt Nickel Manganese Oxide
Cas Number:
37348-84-8
Molecular formula:
Ni1-x-yMnxCoyOz with Me=Ni+Mn+Co=1 and Ni/Me= 0.45-0.98 Mn/Me= 0.01-0.35 Co/Me= 0.01-0.35 O/Me= 1.00-1.33
IUPAC Name:
Cobalt Nickel Manganese Oxide
Test material form:
solid
Specific details on test material used for the study:
Generic composition, using the typical or maximum concentration for each elemental consituent.

Results and discussion

Effect concentrationsopen allclose all
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
<= 0.01 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: most sensitive species
Remarks on result:
other: worst-case composition
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
> 0.01 - <= 0.1 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: most sensitive species
Remarks on result:
other: typical composition

Any other information on results incl. tables

According to MeClas, the typical substance composition is classified as Aq.Chronic Cat.2 to the environment.

According to MeClas, the worst-case substance composition is classified as Aq.Chronic Cat.1 to the environment.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Good quality estimate of the EC10/NOEC of pNMC oxide - typical and worst-case composition.
The typical substance composition is classified as Aq.Chronic Cat.2 to the environment resulting in a EC10/NOEC between 0.01 and 0.1 mg/L.
The worst-case substance composition is classified as Aq.Chronic Cat.1 to the environment resulting in a EC10/NOEC <= 0.01 mg/L.
Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a generic pNMC oxide sample of the substance using dissolution data that were generated with pNMC oxide-samples. 

 

Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a soluble composition relevant for classification.

 

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