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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeClas tool
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: software
Title:
Unnamed
Year:
2020

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity potential of pNMC hydroxide (generic composition) was determined by classifying based on the Mixture rules from EU CLP (additivity formula of classified components to derive hazard class) and back calculation to the corresponding acute toxicity range estimate.

Test material

impurity 1
Reference substance name:
Total unspecified impurities
IUPAC Name:
Total unspecified impurities
Constituent 1
Reference substance name:
Cobalt Nickel Manganese Oxide
Cas Number:
37348-84-8
Molecular formula:
Ni1-x-yMnxCoyOz with Me=Ni+Mn+Co=1 and Ni/Me= 0.45-0.98 Mn/Me= 0.01-0.35 Co/Me= 0.01-0.35 O/Me= 1.00-1.33
IUPAC Name:
Cobalt Nickel Manganese Oxide
Test material form:
solid

Results and discussion

Effect levels
Dose descriptor:
other: acute toxicity estimate ATE
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: prediction

Any other information on results incl. tables

According to MeClas, the substance is not classified as Acute toxicity Dermal.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information
Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case sample of the substance using mineralogical information from the representative sample. 

 

Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.

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