Reaction Mass of Valencene and Aristolochene

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Erratum to Monograph ''Valencene''

Author:

Letizia, C.S., Cocchiara, J., Wellington, G.A., Funk, C. and Api, A.M.

Year:

2001

Bibliographic source:

[Food and Chemical Toxicology 38 Supplement 3 (2000) S235-S236]. Food and Chemical Toxicology, 7(39), p.757.

Materials and methods

Study type:

study with volunteers

Endpoint addressed:

skin irritation / corrosion

Test guideline

Guideline:

other: Methodology not reported

GLP compliance:

not specified

Test material

Test material information

1

Reference substance name:

[1R-(1α,7β,8α)]-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylvinyl)naphthalene

EC Number:

225-047-6

EC Name:

[1R-(1α,7β,8α)]-1,2,3,5,6,7,8,8a-octahydro-1,8a-dimethyl-7-(1-methylvinyl)naphthalene

Cas Number:

4630-07-3

Molecular formula:

C15H24

IUPAC Name:

3-isopropenyl-4a,5-dimethyl-1,2,3,4,4a,5,6,7-octahydronaphthalene

Method

Type of population:

general

Subjects:

healthy male volunteers

Ethical approval:

not specified

Route of exposure:

dermal

Reason of exposure:

intentional

Exposure assessment:

measured

Details on exposure:

A closed patch test with 5% valencene in petrolatum on the backs of 25 healthy, male volunteers with observation after 48-hours