Sodium sarcosinate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study meets generally accepted scientific principles (non-GLP)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Principles of method if other than guideline:

BASF-TEST: Several groups of 5 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in suitable vehicle. Group-wise documentation of clinical signs was performed over the 7 day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose.

GLP compliance:

no

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Sodium sarcosinate

EC Number:

224-338-5

EC Name:

Sodium sarcosinate

Cas Number:

4316-73-8

Molecular formula:

C3H6NNaO2

IUPAC Name:

sodium (methylamino)acetate

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

DOSAGE PREPARATION
- Stock solutions prepared: 2% for the 200 mg/kg dose group, 20% for the 1600 mg/kg dose group, 30% for the 3200 and 6400 dose group
- Dose volume applied: 10 ml/kg bw for the 200 mg/kg bw dose group; 8 ml/kg bw for the 1600 mg/kg bw dose group; 10.66 ml/kg bw for the 3200 mg/kg bw dose group; 21.4 ml/kg bw for the 6400 mg/kg bw dose group.

Doses:

200; 1600; 3200; 6400 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 6 400 mg/kg bw

Mortality:

At the highest dose (6400 mg/kg bw) one male died three days after application.

Clinical signs:

other: 3200, 6400 mg/kg bw: directly after application irregular respiration, convulsions; reversible within 2 days 200, 1600 mg/kg bw: piloerection; reversible within one day

Gross pathology:

Animal which died: intestinal paralysis, dilatation of the stomach which was filled with yellow aqueous substance
Animals sacrificed:
3200, 6400 mg/kg bw: bronchitis in 6 animals
1600 mg/kg bw: slight dilatation of the stomach in two animals
200 mg/kg bw: nothing abnormal detected