Sodium sarcosinate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable screening method

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Inhalation hazard test as in the annex of the guideline

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Sodium sarcosinate

EC Number:

224-338-5

EC Name:

Sodium sarcosinate

Cas Number:

4316-73-8

Molecular formula:

C3H6NNaO2

IUPAC Name:

sodium (methylamino)acetate

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: water

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

nominal concentration: 3.41 mg/l

No. of animals per sex per dose:

6 (tests were performed in 2 trials with 3 animals/sex/trial)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

3.41 mg/L air (nominal)

Exp. duration:

8 h

Remarks on result:

other: No mortalities observed

Mortality:

No mortalities observed

Clinical signs:

other: No abnormalities observed

Body weight:

not determined

Gross pathology:

One animal suffered from bronchitis