L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

GLP compliance:

no

Type of method:

effusion method: Knudsen cell

Test material

Test material information

Constituent 1

Reference substance name:

ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate

Cas Number:

440667-78-7

Molecular formula:

C20H25N3O5

IUPAC Name:

ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate

Test material form:

solid: particulate/powder

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Test no.:

#9

Temp.:

150 °C

Vapour pressure:

0.07 Pa

Vapour pressure 2

Key result

Test no.:

#8

Temp.:

135 °C

Vapour pressure:

0.024 Pa

Vapour pressure 3

Key result

Test no.:

#7

Temp.:

120 °C

Vapour pressure:

0.004 Pa

Applicant's summary and conclusion

Conclusions:

For the test substance L-Tyrosine, N-acetyl-3,5-diamino-O-(4-methoxyphenyl)-, ethyl ester, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: 4.35 * 10-09 Pa
Vapour pressure at 25 °C: 1.08 * 10-08 Pa
The linear regression of log p vs. 1/T gave a correlation coefficient r of - 0.9934, showing good repeatability and precision. Therefore, the determination is considered as valid.