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EC number: 617-441-5 | CAS number: 83121-18-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.006 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.001 mg/kg sediment dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0 mg/kg sediment dw
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.004 mg/kg soil dw
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 0.67 mg/kg bw
- Assessment factor:
- 3 000
Additional information
The PNEC derivation acc. to EPM was justified as follows:
PNEC freshwater sediment: 0.0162 µg/kg dw
K_(susp-water) = 652.45
RHO_(susp) = 1150
Conversion factor (wwt -> dwt): 4.6
PNEC_freshwater sediment= (K_(susp-water)/ RHO_(susp)) * PNEC_freshwater * 1000
PNEC marine water sediment: 0.00112 µg/kg dw
K_(susp-water) = 652.45
RHO_(susp) = 1150
Conversion factor (wwt -> dwt): 4.6
PNEC_marine sediment = (K_(susp-water)/ RHO_(susp)) * PNEC_marinewater * 1000
Conclusion on classification
a.s. = active substance = Teflubenzuron
Conclusion on classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
Classification related information
Biodegradability: not readily biodegradable (1% biodegradation after 28 days, OECD 301B)
Biodegradation half-life in freshwater: 29.6 days at 12 °C (entire system)
Half-life for hydrolysis: DT50 = 8.7 days at a temperature of 25 °C and a pH of 9
Log Pow: 4.98 at 20 °C
Aquatic acute toxicity
- Aquatic invertebrates: EC50 (48 h) = 0.0028 mg a.s./L (mean measured, Daphnia magna, OECD 202)
- Algae: ErC50 (96 h) ≥ 0.02 mg a.s./L (nominal, Desmodesmus subspicatus, EU Method C.3)
- Fish: LC50 (96 h) > 0.0065 mg a.s./L. (arithm. mean measured, L. macrochirus, OECD 203)
Aquatic chronic toxicity
- Algae: NOEC (96 h) >= 0.02 mg a.s./L (nominal, Desmodesmus subspicatus, EU Method C.3)
- Aquatic invertebrates: key values for freshwater and marine species are available
Freshwater: NOEC (21 d) = 0.062 µg a.s./L (nominal concentration, Daphnia magna, OECD 211)
Marine water: NOEC (27 d) = 0.043 µg a.s./L (mean measured, Mysidopsis bahia, EPA 540/9-82-024 ASTM Standard E1191-90)
- Fish: NOEC (28 d) > 0.0186 mg a.s./L (arithm. mean measured, Oncorhynchus mykiss, OECD 215)
Conclusion
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. Teflubenzuron is not rapidly degraded. The substance was found to be not readily biodegradable. Further, the DT50 for biodegradation in the freshwater phase was determined to be 29.6 days at 12 °C. The DT50 for hydrolysis was measured to be 8.7 days at a temperature of 25 °C and a pH of 9. Following worst case assumption the substance is considered to be not rapidly degraded from aquatic compartments in accordance with the criteria given in section 4.1.2.9.5 in Annex I to Regulation (EC) No 1272/2008 (CLP). The most sensitive short-term test for the aquatic compartment was to aquatic invertebrates with Daphnia magna. The test revealed an EC50 (48 h) of 0.0028 mg a.s./L (mean measured). For the same species the lowest freshwater long-term result was determined: NOEC (21 d) = 0.062 µg a.s./L (nominal concentration, Daphnia magna, OECD 211). For marine species, Mysidopsis bahia was most sensitive with a NOEC (27 d) of 0.043 µg a.s./L (mean measured concentrations). The log Pow was determined to be 4.98. Based on these results, Teflubenzuron is classified for aquatic short-term (acute) toxicity, Category 1 (H400, Very toxic to aquatic life; M = 100) and for aquatic long-term (chronic) toxicity Category 1 (H410, very toxic to aquatic life with long-lasting effects; M = 1000) according to Regulation (EC) No 1272/2008 (CLP), as amended for the fifteenth time in Regulation (EU) 2020/1182.
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