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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Fatty acid amido propyl dimethylamines: Human health tier II Assessment
Author:
NICNAS
Year:
2019
Bibliographic source:
NICNAS Health Assessment
Report date:
2019

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
not specified in the NICNAS report
GLP compliance:
not specified
Remarks:
Not specified in the NICNAS report
Test type:
other: not specified

Test material

Constituent 1
Reference substance name:
Amides, coco, N-[3-(dimethylamino)propyl]
EC Number:
268-771-8
EC Name:
Amides, coco, N-[3-(dimethylamino)propyl]
Cas Number:
68140-01-2
IUPAC Name:
Amines, C12-18, alkyldimethyl
Test material form:
liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
unchanged (no vehicle)
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 300 - <= 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Remarks:
H302 Harmful if swallowed
Conclusions:
Cocamidopropyl Dimethylamine : Oral Acute Toxicity : LD 50 : 300 - 2000 mg/kg bw

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