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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-11-07 to 2019-11-08
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
20 °C
Vapour pressure:
2 Pa
Temp.:
25 °C
Vapour pressure:
3.5 Pa
Temp.:
50 °C
Vapour pressure:
43 Pa

The vapour pressure was measured in the temperature range of 0 °C to 30 °C. After the measurement a mass loss of approx. 99 % (w/w) was determined.


Table 1: Measured vapour pressures and corresponding temperatures










































Temperature / °C



Vapour pressure / hPa



0



1.8 x 10-3



5



3.3 x 10-3



10



6.4 x 10-3



15



1.2 x 10-2



20



2.1 x 10-2



25



3.3 x 10-2



30



n.e.



20



n.e.



n.e.: not evaluable


The data points measured at 30 °C and 20 °C (decreasing temperature) were not evaluable as the test cell was nearly empty.


From the measured data the parameters A, B and C of the Antoine equation can be derived by regression.


log (p/hPa) = A + B/(C+T[°C])


Table 2: Antoine parameters


















A



12.60944



B



-4192.57



C



273.15



The vapour pressure values lor 20, 25 and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C), using these Antoine constants A, B and C.


Table 3: Vapour pressures


























T / °C



p / hPa



p / Pa



20



2.0 x 10-2



2.0



25



3.5 x 10-2



3.5



50



4.3 x 10-1



43



 

Conclusions:
The vapour pressure of the test item was 2.0 Pa at 20 °C, 3.5 Pa at 25 °C and 43 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was measured in the temperature range of 0 °C to 30 °C. After the measurement a mass loss of approx. 99 % (w/w) was determined. The data points measured at 30 °C and 20 °C (decreasing temperature) were not evaluable as the test cell was nearly empty.


Using the Antoine equation, the constants A, B and B were determined and the vapour pressure values for 20, 25 and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C),. The vapour pressure was calculated to be 2.0 Pa at 20 °C, 3.5 Pa at 25 °C and 43 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was 2.0 Pa at 20 °C, 3.5 Pa at 25 °C and 43 Pa at 50 °C, respectively (reference 4.6-1).

Key value for chemical safety assessment

Vapour pressure:
2 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was measured in the temperature range of 0 °C to 30 °C. After the measurement a mass loss of approx. 99 % (w/w) was determined. The data points measured at 30 °C and 20 °C (decreasing temperature) were not evaluable as the test cell was nearly empty.


Using the Antoine equation, the constants A, B and B were determined and the vapour pressure values for 20, 25 and 50 °C were interpolated (values at 20 °C and 25 °C) and extrapolated (value at 50 °C),. The vapour pressure was calculated to be 2.0 Pa at 20 °C, 3.5 Pa at 25 °C and 43 Pa at 50 °C, respectively.

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