Registration Dossier
Registration Dossier
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EC number: 906-089-0 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames test: Negative (OECD TG 471, GLP)
Additional information
Ames
The substance is tested in the Ames test (OECD TG 471) and following GLP. The following concentrations were tested in 3 independent experiments, 1.7, 5.4, 17, 52, 164, 512, 1600 and 5000 μg/plate. In the first mutation experiment, cytotoxicity was seen as evidenced by a decrease in the number of revertants, reduction of the bacterial background lawn and/or the presence of microcolonies, in the absence of S9-mix in TA98 and in the presence of S9-mix in TA1535, TA1537 and TA98. In the second mutation experiment, cytotoxicity was seen, as evidenced by a decrease in the number of revertants, reduction of the bacterial background lawn and/or the presence of microcolonies, in all tester strains in the absence and presence of S9-mix, except in WP2uvrA in the absence of S9-mix. Because of plate infections and excessive toxicity in tester strain TA100 in the second experiment, an additional third mutation experiment was performed. Cytotoxicity was seen, as evidenced by a decrease in the number of revertants, reduction of the bacterial background lawn and/or the presence of microcolonies, in the absence and presence of S9-mix. There were no positive results in all strains. Based on this the substance is not mutagenic in this test.
Justification for classification or non-classification
Based on the results of the Ames test, the substance does not need to be classified for genotoxicity according to EU CLP (EC 1272/2008 and its amendments).
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