Copper Chelate Complex

Partition coefficient

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

partition coefficient

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

September - November 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

Principles of method if other than guideline:

The test item is not stable and hydrolyses within a few minutes when in contact with water: Therefore, it was decided to measure the partition coefficient of the degradation product itself.

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

- Storage conditions: Keep in a cool dry place. Store under nitrogen at room temperature; keep away from any humidity and sunlight.

Analytical method:

high-performance liquid chromatography

photometric method

Key result

Type:

log Pow

Partition coefficient:

0.885

Temp.:

25 °C

pH:

7.64

Conclusions:

The Log Pow (n-octanol/water) of the test item was determined to be 0.885 at 25 °C.

Executive summary:

The partition coefficient n-octanol/water (Pow) was measured according to OECD test method no. 117, using the HPLC-method with UV-detection. The substance to be registered is not stable and hydrolyses within a few minutes when in contact with water: Therefore, it was decided to measure the partition coefficient of the degradation product itself. The Log Pow (n-octanol/water) of the degradation product was determined to be 0.885 at 25 °C.

Reference 2

Endpoint:

partition coefficient

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Principles of method if other than guideline:

The substance to be registered is a sparingly soluble substance, which hydrolyses in aqueous solutions immediately (t1/2 < 1 minute) resulting in an organic degradation product (LZ399) and copper. Therefore the Log Pow was determined on the degradation product LZ399. The Log Pow of the Copper Chelate complex cannot be calculated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Key result

Remarks on result:

not determinable because of methodological limitations

Conclusions:

The Log Pow of the Copper Chelate complex cannot be calculated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Executive summary:

The substance to be registered is a sparingly soluble substance, which hydrolyses in aqueous solutions immediately (t1/2 < 1 minute) resulting in an organic degradation product (LZ399) and copper. Therefore the Log Pow was determined on the degradation product LZ399.The Log Pow of the Copper Chelate complex cannot be calculated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Reference 3

Endpoint:

partition coefficient

Data waiving:

study technically not feasible

Justification for data waiving:

the study does not need to be conducted because the substance decomposes

Key result

Remarks on result:

not determinable because of methodological limitations

Reference 4

Endpoint:

partition coefficient

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

no guideline followed

Principles of method if other than guideline:

The substance to be registered is a sparingly soluble substance, which hydrolyses in aqueous solutions immediately (t1/2 < 1 minute) resulting in an organic degradation product (LZ399) and copper. Therefore the Log Pow was determined on the degradation product LZ399.The Log Pow of the Copper Chelate complex cannot be calculated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Key result

Remarks on result:

not determinable because of methodological limitations

Conclusions:

The Log Pow of the Copper Chelate complex cannot be calculated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Executive summary:

The substance to be registered is a sparingly soluble substance, which hydrolyses in aqueous solutions immediately (t1/2 < 1 minute) resulting in an organic degradation product (LZ399) and copper. Therefore the Log Pow was determined on the degradation product LZ399.The Log Pow of the Copper Chelate complex cannot be calculated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Description of key information

The substance to be registered is a sparingly soluble organic metal complex hydrolyzing within a few minutes when in contact with wate, hence it's Log Pow for the substance to be registered can not be determined using the standard methods. Therefore, it was decided to measure the partition coefficient of the degradation product (LZ 399) itself. The Log Pow (n-octanol/water) of the degradation product was determined to be 0.885 at 25 °C. The log Pow for the Copper Chelate Complex cannot be estimated, as the calculation methods such as EPIWIN are not applicable to metal complexes.

Key value for chemical safety assessment

Log Kow (Log Pow):

0.885

at the temperature of:

25 °C