Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Hydrolysis in function of pH:
In this study the hydrolysis was determined based on the OECD Guideline no. 111. Since the test item was expected to hydrolyze rather fast, a preliminary test with conditions modified from the conditions given in the guideline, was carried out. The test was carried out at 20 °C ± 0.5 °C. Samples of the test item in buffer solution pH 4, pH 7 and pH 9 were prepared and incubated for 30 minutes. Samples were taken immediately after preparation, after 10 minutes and 30 minutes. Since the test item itself cannot be determined by a suitable analytical method, the samples were analysed for the tentantive hydrolysis product LZ 399. The analysis of LZ 399 was carried out by GC/FID detection - using matrix matched standards - after saturation of the samples with an excess of sodium chloride and extraction with ethylacetate.
The test item is not stable in aqueous buffer pH 4, 7 and 9 and immediately hydrolyses completely into LZ 399. Thus, the half-life time for hydrolytical degradation is < 1 minute for buffer solutions at pH 4, 7 and 9. Therefore, no main study had to be performed.
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