Registration Dossier
Registration Dossier
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EC number: 953-470-2 | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Remarks:
- Dissolution of metal nanomaterials
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Ongoing
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline for determining the dissolution of metal nanomaterials in aquatic media
- Version / remarks:
- Draft version.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Series on Testing and Assessment No. 318: “Guidance document for the testing of dissolution and dispersion stability of nanomaterials, and the use of the data for further environmental testing and assessment”
- Version / remarks:
- Version: 2021.
Remark: This guidance document is the one that refers to "OECD Draft Guideline for determining the dissolution of metal nanomaterials in aquatic media" as a relevant method for assessing dissolution rate of metal nanomaterials.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Series on Testing and Assessment No. 317: "Guidance document on aquatic and sediment toxicological testing of nanomaterials"
- Version / remarks:
- Version: 2021.
Remark: The preconisations of this guidance document were followed to prepare the test item suspension on which the dissolution rate was measured.
- Principles of method if other than guideline:
- Annex VII of REACH Regulation (EC) No 1907/2006 recommends to assess the dissolution rate of nanomaterials. For this, OECD Series on Testing and Assessment No. 318 “Guidance document for the testing of dissolution and dispersion stability of nanomaterials, and the use of the data for further environmental testing and assessment” refers to "OECD Draft Guideline for determining the dissolution of metal nanomaterials in aquatic media". In the absence of any published test guideline to assess this endpoint of nanomaterials dissolution rate, it was decided to follow this draft guideline, by applying it to a test item suspension prepared as preconised under OECD Series on Testing and Assessment No. 317: "Guidance document on aquatic and sediment toxicological testing of nanomaterials".
- GLP compliance:
- yes
- Type of method:
- other: Static method as described under "OECD Draft Guideline for determining the dissolution of metal nanomaterials in aquatic media" applied to a test item suspension prepared as preconised under OECD Guidance Document No. 317.
Test material
- Reference substance name:
- Cerium gadolinium oxide
- EC Number:
- 953-470-2
- Molecular formula:
- Gd2CeO5
- IUPAC Name:
- Cerium gadolinium oxide
- Test material form:
- solid: nanoform
Constituent 1
Results and discussion
Water solubility
- Key result
- Remarks on result:
- other: Results not yet available; see in the field "Overall remarks, attachments" for further information.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
