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EC number: 953-470-2
CAS number: -
The study was carried out based on the OECD Guideline 436: Acute Inhalation Toxicity- Acute Toxic Class Method, September 2009.
The substance was administered as a dust by nose-only inhalation for 4 hours to one group of three male and three female Wistar Han rats at a target concentration of 5 mg/L. Mortality and clinical signs were observed daily during the 14-day post observation period and body weights were determined on Days 1, 2, 4, 8 and 15. Macroscopic examination was performed after terminal sacrifice (Day 15).
The time-weighted mean actual concentration was 5.2 ± 0.15 mg/L.
The particle size distribution was characterized twice during the exposure period. The MMAD was 4.2 µm (GSD 1.8) and 3.5 µ.m (GSD 2.0).
No mortality occurred.
During exposure, increased and irregular breathing was seen in all animals. After exposure, increased and irregular breathing and hunched posture were observed up to 3 hours after exposure Day 1 and erected fur were seen up to Day 3 in all animals. Afterwards, no clinical signs were noted up to the end of the observation period.
Overall body weight gain in males and females was within the range expected for rats of this strain and age used in this type of study and were therefore considered not indicative of toxicity. No abnormalities were found at macroscopic postmortem examination of the animals.
The inhalation LC50-4h value of the test item in Wistar Han rats was established to exceed 5 mg/L.
According to these results, the test substance does not have to be classified according to GHS and CLP criteria.
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