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Physical & Chemical properties

Partition coefficient

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partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 13 to July 24, 2009
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
The study was conducted according to an internationally recognised method, and under GLP, with deviation on maximum phase concentration. The substance is adequately identified, but the composition is incomplete. Therefore validation applies with restrictions.
according to guideline
EU Method A.8 (Partition Coefficient - Shake Flask Method)
max phase concentration 0.01M exceeded
GLP compliance:
yes (incl. QA statement)
effective from 16/07/2008
Type of method:
flask method
Partition coefficient type:
Specific details on test material used for the study:
- Physical state: Pale yellow translucent liquid
- Storage condition of test material: Stored at room temperature protected from direct sun light.
Analytical method:
gas chromatography
Key result
log Pow
Partition coefficient:
20 °C
Details on results:
Estimated value:
QSAR determination gave 6.37 as the estimated value (Source: kowwin v. 1.67, EPI Suite, EPA).

ratio ratio 1:10 ratio 2:10 ratio 1:20
replicate vessel 1 2 1 2 1 2
log Kow 5,06 5,18 5,18 5,13 5,10 5,13
mass balance 105,0% 104,1% 104,3% 106,3% 102,1% 108,6%

Mean Log Pow and standard deviation = 5.13 ± 0.05

The observed interval within the six LogPow values was [5.06 - 5.18] and the validity criterion was fulfilled: The six LogPow values fell within a range of less than ± 0.3 units.

The pH of the water phase was measured as 5.88.

The substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow >4 ).
Executive summary:

The partition coefficient of the test item was determined under GLP according to EU A.8 guideline, shake flask method.

Determinations were conducted in duplicate for three solvents ratio (1:10, 1:20, 2:10, 2 replicates each), concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.

The log Kow has been determined to be 5.13 at 20°C (and pH 5.88).

Description of key information

The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.

The substance has potential for bioaccumulation (log Kow >4).

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available.

Despite restrictions due to deviation in maximum phase concentration, and incomplete test item identification, it is considered as key study, and the result is retained as key data.